![]() Another question concerns use of contrast media in patients with prior reactions or allergies. For one frequent question-is informed consent necessary before all contrast media injections-the simple answer is no. Some questions are easily answered and others still require extensive investigation. Management is symptomatic and similar to the management of other drug-induced skin reactions.Īlthough iodinated contrast agents are safe and widely used, adverse events occur and questions remain about their use, safety, and interactions. Most skin reactions are self-limiting and resolve within a week. Patients at increased risk of late skin reactions are those with a history of previous contrast medium reaction and those on interleukin-2 treatment. The majority of late skin reactions after contrast medium exposure are probably T-cell-mediated allergic reactions. Late reactions appear to be commoner after non-ionic dimers. A significant proportion of these reactions is unrelated to the contrast medium however, allergy-like skin reactions are well-documented side effects of contrast media with an incidence of approximately 2%. Late adverse reactions after intravascular iodinated contrast medium include symptoms such as nausea, vomiting, headache, itching, skin rash, musculoskeletal pain, and fever. The report and guidelines were discussed at the 8th European Symposium on Urogenital Radiology in Genoa. Based on the available information, simple guidelines have been drawn up. An extensive literature search was carried out and summarized in a report. The Contrast Media Safety Committee of the European Society of Urogenital Radiology decided to review the literature and to issue guidelines. They have received increasing interest over the past decade, but their prevalence remains uncertain and their pathophysiology is not fully understood. Late adverse reactions to intravascular iodinated contrast media are defined as reactions occurring 1 h to 1 week after contrast medium injection. No preference was given to either technique when evaluating the Ao or rCPA but the BT technique was shown to be shorter in duration and resulted in less DLP than the TB technique. The mean DLP did not differ significantly between the two techniques (p = 0.17). The mean mA for the BT technique was significantly lower than the TB technique (p = 0.03), as was the mean CTDI(vol) (p = 0.001). The BT technique was conducted in a significantly shorter time period than the TB technique (p = 0.03). The attenuation in the Ao (BT = 660 52 HU ± 138 49 HU, TB = 469 82 HU ± 199 52 HU, p = 0.13) and in the rCPA (BT = 606 34 HU ± 143 37 HU, TB = 413 72 HU ± 174.99 HU, p = 0.28) did not differ significantly between the two techniques. ![]() ![]() Additional observations included the study duration, milliAmpere (mA), computed tomography dose index volume (CTDI) and dose length product (DLP). ![]() Mean attenuation in HU was measured in the aorta (Ao) and right caudal pulmonary artery (rCPA). The full dose of the contrast agent was then administered and the scans were conducted at optimal times as identified from time attenuation curves. For the TB technique, the dogs received a test dose of 15% of 2 mL/kg of 300 mgI/mL iodinated contrast agent, followed by a series of low dose sequential scans. Scans were initiated when the contrast in the aorta reached 150 Hounsfield units (HU). For the BT technique, 2 mL/kg of 300 mgI/mL iodinated contrast agent was injected intravenously. ![]() MATERIALS AND METHODS: Eight different types of iodinated contrast media (three ionic and five non-ionic) were exposed to x-rays and gamma rays irradiation.Computed tomography thoracic angiography studies were performed on five adult beagles using the bolus tracking (BT) technique and the test bolus (TB) technique, which were performed at least two weeks apart. OBJECTIVE: The purpose of the present study was to investigate the influence of ionizing radiation from x-rays and gamma rays on the molecular structure stability of several radiologic contrast media employed in diagnostic imaging by means of ¹H and 13C nuclear magnetic resonance spectroscopy. Keywords: Imaging diagnosis, Contrast media, Ionizing radiation, Nuclear magnetic resonance spectroscopy, X-rays, Gamma raysĭescritores: Diagnóstico por imagem, Meios de contraste, Radiação ionizante, Espectroscopia de ressonância magnética nuclear, Raios X, Raios gama Evaluation of contrast media submitted to ionizing radiationĪutho(rs): Kátia Elisa Prus Pinho, Pedro Miguel Gewehr, Caroline Werner Pereira da Silva, Andersson Barison, João Gilberto Tilly Júnior, Danyel Scheidegger Soboll ![]()
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